Localization of the gene encoding human Factor V to chromosome 1q21–25 |
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| Authors: | H. Wang D. C. Riddell E. R. Guinto R. T. A. MacGillivray J. L. Hamerton |
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| Affiliation: | Department of Human Genetics, University of Manitoba, Winnipeg, Canada. |
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| Abstract: | The gene encoding human coagulation Factor V (FV), one of the cofactors in the blood clotting process, has been mapped to chromosome 1 by both Southern hybridization to DNA from human-hamster somatic cell hybrids and in situ hybridization. The whole plasmid pUC3A containing a 1.5-kb cDNA sequence for FV was 32P-labeled for Southern analysis and 3H-labeled for in situ hybridization to metaphase chromosomes. The results localized the FV gene to the region of 1q21-25. |
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