Multi-centre parallel arm randomised controlled trial to assess the effectiveness and cost-effectiveness of a group-based cognitive behavioural approach to managing fatigue in people with multiple sclerosis |
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| Authors: | Peter W Thomas Sarah Thomas Paula Kersten Rosemary Jones Alison Nock Vicky Slingsby Colin Green Roger Baker Kate Galvin Charles Hillier |
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| Affiliation: | (1) Dorset Research and Development Support Unit, Poole Hospital NHS Foundation Trust, Poole, Dorset, UK;(2) The School of Health and Social Care, Bournemouth University, Bournemouth, Dorset, UK;(3) School of Health Sciences, University of Southampton, Hampshire, UK;(4) Joint Clinical Research Unit, BrAMS Building, University Hospitals and Frenchay Hospital Bristol, UK;(5) Dorset MS Service, Poole Hospital NHS Foundation Trust, Poole, Dorset, UK;(6) Peninsula Medical School, University of Exeter, Devon, UK;(7) Dorset Healthcare NHS Foundation Trust, Bournemouth, Dorset, UK |
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| Abstract: | Background Fatigue is one of the most commonly reported and debilitating symptoms of multiple sclerosis (MS); approximately two-thirds of people with MS consider it to be one of their three most troubling symptoms. It may limit or prevent participation in everyday activities, work, leisure, and social pursuits, reduce psychological well-being and is one of the key precipitants of early retirement. Energy effectiveness approaches have been shown to be effective in reducing MS-fatigue, increasing self-efficacy and improving quality of life. Cognitive behavioural approaches have been found to be effective for managing fatigue in other conditions, such as chronic fatigue syndrome, and more recently, in MS. The aim of this pragmatic trial is to evaluate the clinical and cost-effectiveness of a recently developed group-based fatigue management intervention (that blends cognitive behavioural and energy effectiveness approaches) compared with current local practice. |
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