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TPA stimulation culture for improved detection of t(11;14)(q13;q32) in mantle cell lymphoma |
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| Authors: | Barouk-Simonet Emmanuelle Andrieux Joris Copin Marie-Christine Grardel-Duflos Nathalie Huyghe Pauline Patte Jean-Hugues Preudhomme Claude Quesnel Bruno Laï Jean-Luc |
| Institution: | Laboratoire de Génétique Médicale, Barre Nord H?pital Jeanne de Flandre, CHRU de Lille, Lille, France. |
| Abstract: | Cytogenetic analysis of mantle cell lymphoma (MCL), characterized by the presence of t(11;14)(q13;q32) translocation, is often difficult because of the low proliferating rate of MCL cells and the presence of normal cells in bone marrow which may interfere with growth of MCL cells. We describe herein a TPA (12-O-tetradecanoylphorbol 13-acetate) stimulated culture to improve detection of t(11;14)(q13;q32) in 20 MCL patients regardless of the samples used. |
| Keywords: | Mantle cell lymphoma Cytogenetics Translocation (11 14)(q13 q32) TPA stimulated culture Improved detection |
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