Reduction of aryl acids by white-rot fungi for the biocatalytic production of aryl aldehydes and alcohols |
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Authors: | A Hage H E Schoemaker J A Field |
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Institution: | (1) Division of Industrial Microbiology, Department of Food Technology and Nutritional Sciences, Wageningen Agricultural University, P.O. Box 8129, 6700 EV Wageningen, The Netherlands e-mail: Annemarie.Hage@imb.ftns.wau.nl Tel.: +31-317-483393 Fax: +31-317-484978, NL;(2) DSM Research, Bio-organic Chemistry, P.O. Box 18, 6160 MD Geleen, The Netherlands, NL |
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Abstract: | Ligninolytic basidiomycetes were screened for their ability to reduce aryl acids to the corresponding aldehydes and alcohols.
Seven fungal strains converted p-anisic acid in high molar yields to the reduced products. The white-rot fungus Bjerkandera sp. strain BOS55 was one of the best reducing strains and was highly tolerant towards high concentrations of different aromatic acids. It
was tested for the reduction of p-anisic, veratric, 3-chloro-4-methoxybenzoic, 3,5-dichloro-4-methoxybenzoic, 3,4-dichlorobenzoic, 4-fluorobenzoic, and 3-nitrobenzoic
acids. All of these compounds were reduced to their corresponding aldehydes and alcohols.
Received: 22 March 1999 / Received revision: 12 July 1999 / Accepted: 1 August 1999 |
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