Structural and genetic analysis of the BldB protein of Streptomyces coelicolor |
| |
Authors: | Eccleston Marcus Ali Reem Ahmed Seyler Richard Westpheling Janet Nodwell Justin |
| |
Institution: | Antimicrobial Research Centre and Department of Biochemistry, McMaster University, Hamilton, Ontario, Canada L8N 3Z5. |
| |
Abstract: | We have demonstrated that the bldB gene of Streptomyces coelicolor is required for the formation of aerial hyphae and the synthesis of antibiotics. We also found that BldB forms a higher-order complex (most likely a dimer) and that amino acid residues 20 to 78 are important for this interaction. This region is conserved in the BldB family, suggesting that dimer formation may be a common feature of these proteins. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|