| miR-26家族与肿瘤关系的研究进展 |
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| 引用本文： | 刘放,高晓健,陆霞,张婷婷,李墨林.miR-26家族与肿瘤关系的研究进展[J].生命科学,2014(11):1222-1228. |
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| 作者姓名： | 刘放 高晓健 陆霞 张婷婷 李墨林 |
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| 作者单位： | 大连医科大学;大连医科大学病理生理学教研室; |
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| 基金项目： | 辽宁省自然科学基金项目(2014023041);辽宁省教育科学“十二五”规划2014年度立项课题(JG14DB119) |
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| 摘 要： | miR-26家族是由miR-26a、miR-26b、miR-1297及miR-4465等序列相似、结构相仿、种子区序列相同(UCAAGUA)的微小RNA(microRNAs,miRNAs)组成。多种组织细胞分化过程中伴有mi R-26家族表达的增加,其异常表达与特发性肺纤维化、原发性胆汁性肝硬化、多发性硬化及阿尔茨海默病等有关。近年研究报道,多种肿瘤组织亦存在mi R-26基因表达紊乱,并与肿瘤的发生发展密切相关。就miR-26家族及其调控的靶基因与肿瘤关系的研究进展进行综述。
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| 关 键 词： | miR-26家族 靶基因 恶性肿瘤 调控 |
Progress on the relationship between miR-26 family members and malignant tumors |
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| Institution: | LIU Fang, GAO Xiao-Jian, LU Xia, ZHANG Ting-Ting, LI Mo-Lin (1 Grade 2010, Seven-year Program of Clinical Medicine, Dalian Medical University, Dalian 116044, China; 2 Department of Pathophysiology, Dalian Medical University, Dalian 116044, China) |
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| Abstract: | miR-26 family is composed of 4 miRNAs, including miR-26a, miR-26b, miR-1297 and miR-4465, which share same seed region （UCAAGUA） and similar sequence and structure. It is known the expression of miR-26 members was increased during osteogenic differentiation, smooth muscle cell （SMC） differentiation and neurogenesis, and etc. The disturbance of miR-26 family gene expression was related with biliary cirrhosis, pulmonary fibrosis, multiple sclerosis and Alzheimer’s disease, etc. It was reported recently the disturbance of miR-26 expression existed in tumors and it might play an important role in tumorigenesis and tumor development. In this review, the progress on the relationship between miR-26 family and their target genes and malignant tumors are summarized. |
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| Keywords: | miR-26 family target genes malignant tumors regulation |
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