Transversal dose distribution optimization for laser-accelerated proton beam medical applications by means of Geant4 |
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| Affiliation: | 1. Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali del Sud, Via Santa Sofia 62, Catania, Italy;2. School of Mathematics and Physics, Queens University Belfast, United Kingdom;3. Physics and Astronomy Department, University of Catania, Via S. Sofia 64, Catania, Italy;4. Institute of Physics ASCR, v.v.i (FZU), ELI-Beamlines Project, 182 21 Prague, Czech Republic;5. National Physical Laboratory, CMES – Medical Radiation Science Hampton Road, Teddington, Middlesex, TW11 0LW UK;1. Digital Medical Research Center, School of Basic Medical Sciences, Fudan University, Shanghai, China;2. Shanghai Key Laboratory of Medical Imaging Computing and Computer Assisted Intervention, Shanghai, China;1. Centre for Medical Radiation Physics, University of Wollongong, NSW, 2522, Australia;2. Institute of Materials Engineering, Australian Nuclear Science and Technology Organization, Lucas Heights, NSW 2234, Australia;3. National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan;4. SPA-BIT, Kiev 02232, Ukraine;5. Instituto de Microelectronica de Barcelona, IMB-CNM (CSIC), Spain;6. University of New South Wales, Sydney, NSW 2052, Australia;7. Illawarra Health Medical Research Institute, Australia;1. Department of Physics, Faculty of Science, Al-Balqa Applied University, P.O. Box 2587, Amman 11941, Jordan;2. Prince Sultan Oncology Center, North West Armed Forces Hospitals, Tabuk, P.O. Box 100, Saudi Arabia;3. King Hussein Cancer Center, Amman, Jordan;1. CEA, Centre de Saclay, IRFU, F-91191 Gif-sur-Yvette, France;2. GSI, D-64291 Darmstadt, Germany;3. ATOMKI, P.O. Box 51, H-4001 Debrecen, Hungary;4. IKP, TU Darmstadt, D-64289 Darmstadt, Germany;1. Massachusetts General Hospital, Harvard Medical School, Boston, USA;2. Department of Mechanical Engineering, Catholic University of Leuven, Leuven, Belgium;3. Department of Radiology, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand;4. Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA |
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| Abstract: | The main purpose of this paper is to quantitatively study the possibility of delivering dose distributions of clinical relevance with laser-driven proton beams. A Monte Carlo application has been developed with the Geant4 toolkit, simulating the ELIMED (MEDical and multidisciplinary application at ELI-Beamlines) transport and dosimetry beam line which is being currently installed at the ELI-Beamlines in Prague (CZ). The beam line will be used to perform irradiations for multidisciplinary studies, with the purpose of demonstrating the possible use of optically accelerated ion beams for therapeutic purposes. The ELIMED Geant4-based application, already validated against reference transport codes, accurately simulates each single element of the beam line, necessary to collect the accelerated beams and to select them in energy. Transversal dose distributions at the irradiation point have been studied and optimized to try to quantitatively answer the question if such kind of beam lines, and specifically the systems developed for ELIMED in Prague, will be actually able to transport ion beams not only for multidisciplinary applications, such as pitcher-catcher nuclear reactions (e.g. neutrons), PIXE analysis for cultural heritage and space radiation, but also for delivering dose patterns of clinical relevance in a future perspective of possible medical applications. |
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| Keywords: | Laser-driven ions ELIMED beam line Geant4 Medical applications Transversal dose distributions |
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