Thermoluminescence dosimetry of the dose received by scrotum and testes in radiotherapy of rectal cancer,compared to the point doses calculated by 3D-planning software |
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| Institution: | 1. Radiation Oncology Research Centre, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran;2. Radiation Oncology Department, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran;3. Radiation Physics Department, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran;2. Department of Radiation Oncology, Brigham and Women’s Hospital, Boston, MA;1. Istituto Nazionale di Metrologia delle Radiazioni Ionizzanti, ENEA-INMRI, I-00123 Roma, Italy;2. S. Filippo Neri Hospital, UOSD Fisica Sanitaria, I-00135 Roma, Italy;3. CEA, LIST, Laboratoire National Henri Becquerel (LNE-LNHB), F-91191 Gif-sur-Yvette, France;1. Johns Hopkins University School of Medicine, Department of Radiation Oncology and Molecular Radiation Sciences, Baltimore, Maryland, USA;2. Johns Hopkins University Bloomberg School of Public Health, Department of Biostatistics, Baltimore, Maryland, USA;2. Division of Clinical Radiology Service, Kyoto University Hospital, Kyoto, Japan;1. Department of Physics, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Depok 16424, Indonesia;2. Medical Imaging Research Center, Catholic University of Leuven, Leuven 3000, Belgium;1. Advanced Medical Imaging Center and School of Electrical and Computer Engineering, University of Oklahoma, Norman, OK 73019, USA;2. Department of Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT 84132, USA;3. Department of Radiology, University of Alabama at Birmingham, Birmingham, AL 35249, USA |
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| Abstract: | PurposeRadiation received by the testes in the course of radiotherapy for rectal cancer may cause oligospermia and azospermia. We sought to determine the dose to the scrotum and testes with thermoluminescence dosimetry (TLD), and compare it to the dose calculated by 3D planning software.MethodsThe TLDs were fixed to the scrotum in six points anteriorly and posteriorly in two fractions of radiotherapy. All patients received a 50–50.4 Gy total dose in prone position with 3D-planning. The average dose of TLD measurements was compared to the average of 6 relevant point doses calculated by the planning software.ResultsThe mean scrotal dose of radiation in 33 patients as measured by TLD was 3.77 Gy (7.5% of the total prescribed dose), and the mean of point doses calculated by the planning software was 4.11 Gy (8.1% of the total dose), with no significant difference. A significant relationship was seen between the position of the inferior edge of the fields and the mean scrotal dose (P = .04). Also body mass index (BMI) was inversely related with the scrotal dose (P = .049).ConclusionWe found a dose of about 4 Gy received by the scrotum and testes from a total prescribed dose of 50 Gy in the radiotherapy of rectal carcinoma patients, with TLD measurements confirming testicular dose estimations by the planning software. This dose could be significantly harmful for spermatogenesis. Thus careful attention to the testicular dose in radiotherapy of rectal cancer for men desiring continued fertility is a necessity. |
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| Keywords: | Radiotherapy Testicular dose Rectal cancer |
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