K-edge subtraction synchrotron X-ray imaging in bio-medical research |
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| Affiliation: | 1. Department of Physics, University of Helsinki, Helsinki, Finland;2. Department of Physics, University of Saskatchewan, Saskatoon, Canada;3. Université Grenoble Alpes, EA-7442 Rayonnement Synchrotron et Recherche Médicale, F-38058 Grenoble cedex 9, France;4. Helsinki University Hospital, Helsinki, Finland;1. Department of Obstetrics & Gynaecology, University of Melbourne, Royal Women’s Hospital, Parkville, Victoria 3052, Australia;2. Icon Cancer Centre, Richmond, Victoria 3121, Australia;3. School of Science, RMIT University, Melbourne, Victoria 3001, Australia;4. Alfred Health Radiation Oncology, Alfred Health, Melbourne, Victoria 3004, Australia;5. Department of Surgery, Central Clinical School, Monash University, Melbourne, Victoria 3004, Australia;1. Department of Radiological Science, Konyang University, 158 Gwanjeodong-ro, Daejeon, Republic of Korea;2. Department of Radiological Science, College of Health Science, Gachon University, 191, Hambakmoero, Yeonsu-gu, Incheon, Republic of Korea;1. Canadian Light Source, Saskatoon, SK, Canada;2. Anatomy and Cell Biology, University of Saskatchewan, Saskatoon, SK, Canada;1. Department of Medical Physics and Biomedical engineering, School of Medicine, Tehran University of Medical Science, Tehran, Iran;2. Research Center for Molecular and Cellular Imaging, Tehran University of Medical Sciences, Tehran, Iran;3. Department of Radiology, Johns Hopkins University, Baltimore, MD, USA;4. Department of Electrical & Computer Engineering, Johns Hopkins University, Baltimore, MD, USA;5. Electrical Engineering Department, Sharif University of Technology, Tehran, Iran;6. Department of Nuclear Medicine, Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran;1. Australian Synchrotron, Australian Nuclear Science and Technology Organisation, 800 Blackburn Road, Clayton, Victoria, Australia;2. Equipe d’accueil Rayonnement Synchrotron et Recherche Médicale, Université Grenoble-Alpes, Grenoble, France;3. Centre Hospitalier Universitaire de Grenoble, Grenoble, France;1. Department of Medical Physics, Medical School, University of Crete, P.O. Box 2208, Heraklion 71003, Crete, Greece;2. Department of Radiology, University Hospital of Heraklion, P.O. Box 1352, Heraklion 71110, Crete, Greece;3. Department of Medical Physics, University Hospital of Heraklion, P.O. Box 1352, Heraklion 71110, Crete, Greece;4. Department of Medical Physics, University Hospital of Heraklion, Greece;5. Department of Radiology, Medical School, University of Crete, Greece |
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| Abstract: | High contrast in X-ray medical imaging, while maintaining acceptable radiation dose levels to the patient, has long been a goal. One of the most promising methods is that of K-edge subtraction imaging. This technique, first advanced as long ago as 1953 by B. Jacobson, uses the large difference in the absorption coefficient of elements at energies above and below the K-edge. Two images, one taken above the edge and one below the edge, are subtracted leaving, ideally, only the image of the distribution of the target element. This paper reviews the development of the KES techniques and technology as applied to bio-medical imaging from the early low-power tube sources of X-rays to the latest high-power synchrotron sources. Applications to coronary angiography, functional lung imaging and bone growth are highlighted. A vision of possible imaging with new compact sources is presented. |
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| Keywords: | Synchrotron Bio-medical imaging K-edge subtraction |
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