Bayesian penalized-likelihood reconstruction algorithm suppresses edge artifacts in PET reconstruction based on point-spread-function |
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| Affiliation: | 1. Department of Radiological Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University, Tokyo, Japan;2. Research Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan;3. School of Health Science, International University of Health and Welfare, Ohtawara, Japan;1. Department of Medical Physics and Radiation Protection, University Hospital Olomouc, Olomouc, Czech Republic;2. Clinic of Nuclear Medicine, Faculty of Medicine and Dentistry, Palacký University Olomouc, Olomouc, Czech Republic;1. Department of Clinical Radiology, Oxford University Hospitals NHS Trust, Churchill Hospital, Old Road, Headington, Oxford, Oxfordshire OX3 7LE, UK;2. Department of Oncology, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Headington, Oxford, Oxfordshire OX3 7DQ,UK;3. Radiation Physics and Protection, Oxford University Hospitals NHS Trust, Churchill Hospital, Old Road, Headington, Oxford, Oxfordshire OX3 7LE, UK;1. QUART (Quality Assurance in Radiological Technologies) GmbH, Kirchenweg 7, 85604 Zorneding, Germany;2. Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany;3. Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), C/ Profesor Martín Lagos s/n, 28040 Madrid, Spain;4. Zervides Radiation Protection Services, 5A Onisilou Street, 3075 Limassol, Cyprus;5. University of Nicosia Medical School, 93 Agiou Nikolaou Street, Engomi, 2408 Nicosia, Cyprus;6. Strahlentheraptie Süd, Robert-Weixler-Straße 50, 87439 Kempten, Germany;7. AIKAmed, Wasfi Al-Tal St. 217, 11953 Amman, Jordan;8. University Hospital Rechts der Isar, Ismaninger Str. 22, 81675 Munich, Germany;1. Institute of Nuclear Medicine, University College London, UCLH, Euston Road (T-5), London NW1 2BU, UK;2. Institute of Nuclear Medicine, University College London Hospital, UCLH, Euston Road (T-5), London NW1 2BU, UK;3. Department of Computer Science, University College London, Gower Street, London WC1E 6BT, UK;4. Centre for Medical Imaging, University College London, 250 Euston Road, London NW1 2PG, UK;5. Centre for Medical Imaging Computing, University College London, Gower Street, London WC1E 6BT, UK;6. The Centre for Medical Radiation Physics, University of Wollongong, Northfields Avenue, Wollongong NSW 2522, Australia |
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| Abstract: | PurposeThe Bayesian penalized-likelihood reconstruction algorithm (BPL), Q.Clear, uses relative difference penalty as a regularization function to control image noise and the degree of edge-preservation in PET images. The present study aimed to determine the effects of suppression on edge artifacts due to point-spread-function (PSF) correction using a Q.Clear.MethodsSpheres of a cylindrical phantom contained a background of 5.3 kBq/mL of [18F]FDG and sphere-to-background ratios (SBR) of 16, 8, 4 and 2. The background also contained water and spheres containing 21.2 kBq/mL of [18F]FDG as non-background. All data were acquired using a Discovery PET/CT 710 and were reconstructed using three-dimensional ordered-subset expectation maximization with time-of-flight (TOF) and PSF correction (3D-OSEM), and Q.Clear with TOF (BPL). We investigated β-values of 200–800 using BPL. The PET images were analyzed using visual assessment and profile curves, edge variability and contrast recovery coefficients were measured.ResultsThe 38- and 27-mm spheres were surrounded by higher radioactivity concentration when reconstructed with 3D-OSEM as opposed to BPL, which suppressed edge artifacts. Images of 10-mm spheres had sharper overshoot at high SBR and non-background when reconstructed with BPL. Although contrast recovery coefficients of 10-mm spheres in BPL decreased as a function of increasing β, higher penalty parameter decreased the overshoot.ConclusionsBPL is a feasible method for the suppression of edge artifacts of PSF correction, although this depends on SBR and sphere size. Overshoot associated with BPL caused overestimation in small spheres at high SBR. Higher penalty parameter in BPL can suppress overshoot more effectively. |
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| Keywords: | MAP-EM Quantification Contrast Image quality Artifacts |
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