miR-141 suppresses proliferation and motility of gastric cancer cells by targeting HDGF |
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Authors: | Bitao Chen Tao Huang Jun Jiang Lei Lv Hongxing Li Shitao Xia |
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Affiliation: | 1. Department of Gastroenterology, The No.1 People’s Hospital of Jingmen, Jingmen, 448000, China 2. Department of Urology, Wuhan No,1 Hospital, Huazhong University of Science and Technology, Wuhan, 430033, China 3. Department of Oncology, The Central Hospital of Wuhan, Wuhan, 430014, China
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Abstract: | miR-141 belongs to the miR-200 family, and has been found to be associated with numerous human malignancies; however, its role in gastric cancer (GC) has not been examined in detail. Here, we validated that miR-141 was decreased in GC tissues and cell lines. Forced expression of miR-141 significantly repressed GC cell proliferation and colony formation. Furthermore, miR-141 suppressed in vitro migration and invasion of GC cells. Hepatoma-derived growth factor (HDGF) was confirmed to be a direct target of miR-141 in GC cells. The suppressive effects of miR-141 on GC cell proliferation, colony formation, in vitro migration, and invasion were partially mediated by suppressing HDGF expression. Moreover, the expression of HDGF was negatively correlated with miR-141 in GC tissues. Our data suggest that miR-141 might be associated and plays essential role in GC progression. |
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