Inhibition of miR-92b suppresses nonsmall cell lung cancer cells growth and motility by targeting RECK |
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Authors: | Lin Lei Yaping Huang Wenrong Gong |
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Institution: | 1. Department of Oncology, Xiangyang Central Hospital, Xiangyang, 441021, China 2. Department of Respiratory Medicine, Xiangyang Central Hospital, Xiangyang, 441021, China 3. Institute of Oncology, Medical College of Hubei University of Arts and Science, Xiangyang, 441053, China
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Abstract: | microRNAs play critical roles in the progression and metastasis of nonsmall cell lung cancer (NSCLC). miR-92b acts as an oncogene in some malignancies; however, its role in NSCLC remains poorly understood. Here, we found that miR-92b was significantly increased in human NSCLC tissues and cell lines. Inhibition of miR-92b remarkably suppressed cell proliferation, migration, and invasion of NSCLC cells. Reversion-inducing-cysteine-rich protein with kazal motifs (RECK) was identified to be a target of miR-92b. Expression of miR-92b was negatively correlated with RECK in NSCLC tissues. Collectively, miR-92b might promote NSCLC cell growth and motility partially by inhibiting RECK. |
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