Modulations in the intestinal disaccharide hydrolases and membrane dynamics: Effect of non-steroidal anti-inflammatory drugs aspirin and nimesulide |
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Authors: | Naveen Kaushal S N Sanyal |
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Institution: | (1) Department of Biophysics, Punjab University, Chandigarh, 160014, India |
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Abstract: | The present study was designed to evaluate the influence of two commonly prescribed non-steroidal anti-inflammatory drugs
(NSAIDs), aspirin and nimesulide on the biochemical composition and membrane dynamics of rat intestine. Female Wistar rats
were divided into three different groups viz: Group I (Control), Group II (aspirin-treated, 50 mg/kg body weight) and Group III (nimesulide-treated, 10 mg/kg body weight).
After 28 days, biochemical estimations in both drug treated groups showed an increase in sucrase, lactase, maltase and alkaline
phosphatase as compared to the control. Alterations in the intestinal membrane dynamics by fluidity studies and Fourier Transform
Infra Red (FTIR) spectroscopy also showed considerable changes. The alterations in the histoarchitecture of the intestine
were also seen, which correlated well with the changes in structure and composition of the intestine. The use of NSAIDs like
aspirin and nimesulide may cause the gastrointestinal side effects due to initial changes in the enzyme activities and membrane
dynamics. |
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Keywords: | disaccharidases FTIR membrane fluidity non-steroidal anti-inflammatory drugs |
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