The epithelial tight junction: Structure,function and preliminary biochemical characterization |
| |
| Authors: | Bruce R Stevenson James Melvin Anderson Stanley Bullivant |
| |
| Institution: | (1) Department of Biology, Yale University, Kline Biology Tower, P.O. Box 6666, 06511 New Haven, CT, USA;(2) Department of Medicine and Liver Center, Yale University, USA;(3) Department of Anatomy and Cellular Biology, Harvard Medical School, Boston, MA, USA;(4) Present address: Department of Cellular and Molecular Biology, The University of Auckland, Auckland, New Zealand |
| |
| Abstract: | Summary The tight junction, or zonula occludens (ZO), forms a semi-permeable barrier in the paracellular pathway in most vertebrate epithelia. The ZO is the apical-most member of a series of intercellular junctions, collectively known as the junctional complex, found at the interface of the apical and lateral cell surface. This structure not only restricts movement of substances around the cells, but may also serve as a  fence acting to maintain the cell surface compositional polarity characteristic of epithelial cells. The morphology and physiology of the ZO have been well documented and are briefly reviewed here. The biochemistry of this important intercellular junction remains largely unknown, although a tight junction-specific polypeptide called ZO-1 has recently been identified. Preliminary observations regarding the role of this peripheral phosphoprotein in the biology of the ZO are presented. |
| |
| Keywords: | tight junction zonula occludens epithelium junctional complex cell polarity |
| 本文献已被 SpringerLink 等数据库收录！ |
|
