Wnt signaling in the nervous system and in Alzheimer's disease |
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作者单位: | [1]Center for Aging and Regeneration (CARE), Department of Cell and Molecular Biology, Faculty of Biological Sciences, Pontifical Catholic University of Chile,Santiago, Chile [2]Center for Biomedical Research, Faculty of Biological Sciences and Faculty of Medicine, AndrOs Bello University, Santiago, Chile |
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摘 要: | Wnts comprise a large family of proteins that have shown to be part of a signaling cascade that regulates several aspects of develop- ment including organogenesis, mid brain development as welt as stem cell proliferation. Wnt signaling pathway plays different roles in the development of neuronal circuits and also in the adult brain, where it regulates synaptic transmission and plasticity. It has been also implicated in various diseases including cancer and neurodegenerative diseases, reflecting its relevance in fundamental biological pro- cesses. This review summarizes the progress about Wnts function in mature nervous system with a focus on Alzheimer's disease (AD). We discuss the prospects of modulating canonical and non-canonical Wnt signaling as a strategy for neuroprotection. This will include the potential of Wnts to: (i) act as potent regulators of hippocampai synapses and impact in learning and memory; (ii) regulate adult neurogenesis; and finally (iii) control AD pathogenesis.
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关 键 词: | Wnt信号通路 阿尔茨海默氏病 信号转导 神经系统 神经退行性疾病 突触传递 生物过程 神经保护 |
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