Regulating Wnt signaling: a strategy to prevent neurodegeneration and induce regeneration |
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作者单位: | [1]Department of Pharmaco-logy, UCL School of Pharmacy,University College London,London WCIN lAX, UK [2]Department of Clinical andMolecular Biomedicine, Phar-macology Section, MedicalSchool, University of Catania,95125 Catania, Italy [3]0A51 Institute for Researchand Care on Mental Retarda-tion and Brain Aging (IRCCS),Neurapharmacology Section,94018 Tmina, Italy |
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摘 要: | During the past three decades, Wingtess/Int (Wnt)signaling has emerged as an essential regu{ator crucial for neuronal development and maintenance (Inestrosa and Arenas, 201_0). In addition, Wnt signal- ing was recently shown to be involved in the regula- tion of synaptic function and plasticity, which is critical for learning and memory (Oliva et aL, 2013). Deregulation of Wnt signaling has been proposed as a key contributor to the pathogenesis of neurode- generative disorders including Alzheimer's disease (AD) and Parkinson's disease (PD). This increasing knowledge of the specific roles of Wnt signaling cascades during different stages of life has suggested innovative therapeutic strategies for the treatment of neurodegenerative diseases.
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关 键 词: | Wnt 神经元 退行性病变 信号 神经退行性疾病 阿尔茨海默氏病 再生 诱发 |
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