| Phenotypic and functional characteristic of a newly dentified CDS＋Foxp3-CDI03＋ regulatory T cells |
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| 作者姓名： | Ya Liu Qin Lan Ling Lu Maogen Chen Zanxian Xia Jilin Ma Julie Wang Huimin Fan Yi Shen Bernhard Ryffel David Brand Francisco Quismorio Zhongmin Liu David A. Horwitz Anping Xu Song Guo Zheng |
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| 作者单位： | [1]Department of Nephrology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou 510120, China [2]Division of Rheumatology and Immunology, Department of Medicine, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA [3]Institute of Immunology, Shanghai East Hospital at Tongji University, Shanghai200120, China [4]University of Orleans and CNRS UMR7355, 3b rue de la Ferollerie, Orleans 45071, France [5]Veterans Affairs Medical Center, Memphis, TN 38104, USA |
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| 摘 要： | TGF-β and Foxp3 expressions are crucial for the induction and functional activity of CD4＋Foxp3＋ regulatory T （iTreg） cells. Here, we demonstrate that although TGF-β-primed CD8＋ cells display much lower Foxp3 expression, their suppressive capacity is equivalent to that of CD4＋ iTreg cells, and both Foxp3- and Foxp3＋ CD8＋ subsets have suppressive activities in vitro and in vivo. CD8＋Foxp3- iTreg cells produce little IFN-γ but almost no IL-2, and display a typical anergic phenotype. Among phenotypic markers expressed in CD8＋Foxp3- cells, we identify CD103 expression particularly crucial for the generation and function of this subset. Moreover, IL-IO and TGF-β signals rather than cytotoxicity mediate the suppressive effect of this novel Treg population. Therefore, TGF-β can induce both CD8＋Foxp3- and CD8＋Foxp3＋ iTreg subsets, which may represent the unique immunoregulatory means to treat autoimmune and inflammatory diseases.
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| 关 键 词： | 调节性T细胞 细胞表型 功能特征 CDS TGF-β eg细胞 抑制活性 自身免疫 |
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