Regulation of plasma membrane Ca2+ ATPases by lipids of the phosphatidylinositol cycle |
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| Authors: | D Choquette G Hakim A G Filoteo G A Plishker J R Bostwick J T Penniston |
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| Institution: | 1. Section of Biochemistry, Mayo Clinic, Rochester, Minnesota, 55905 USA;2. Department of Neurology, Baylor College of Medicine, Houston, Texas 77030 USA |
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| Abstract: | When the erythrocyte plasma membrane Ca2+ pump is reconstituted into phosphatidylcholine liposomes, the inclusion of small amounts of phosphatidic acid or phosphatidylinositol 4,5-bisphosphate stimulates the enzyme's activity. Other lipids of the phosphatidylinositol cycle (diacylglycerol, phosphatidylinositol) have little effect. The stimulatory effect of phosphatidylinositol 4,5-bisphosphate is greater than that of calmodulin; this lipid also stimulates the plasma membrane Ca2+ ATPase from rat brain. |
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| Keywords: | To whom request for reprints should be addressed |
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