The expression pattern of tomoregulin-1 in urodele limb regeneration and mouse limb development |
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| Authors: | Morais da Silva S Gates P B Eib D W Martens G J Brockes J P |
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| Institution: | Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK. |
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| Abstract: | Tomoregulin-1 (TMEFF1) was first identified as a gene implicated in pituitary secretion in Xenopus laevis. The predicted structure of TMEFF1 is that of a transmembrane protein with a highly conserved cytoplasmic tail, two follistatin domains and one modified EGF domain in its extracellular region. We report the cloning of the newt orthologue, and show that the expression of TMEFF1 is upregulated in the blastema during limb regeneration, and is also expressed in mouse embryonic limb development. |
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