Primary structure characterization of Bothrops jararacussu snake venom lectin |
| |
Authors: | de Carvalho Daniela D Marangoni Sergio Novello José C |
| |
Affiliation: | (1) Instituto de Biologia, Departamento de Bioquímica, LAQUIP, Universidade Estadual de Campinas (UNICAMP), Campinas-SP, 13083-970, Brazil |
| |
Abstract: | The complete amino acid sequence of the lectin from Bothrops jararacussu snake venom (BJcuL) is reported. The sequence was determined by Edman degradation and amino acid analysis of the S-carboxymethylated BJcuL derivative (RC-BJcuL) and from its peptides originated from enzymatic digestion. The sequence of amino acid residues showed that this lectin displays the invariant amino acid residues characterized in C-type lectins. Amino acids analysis revealed a high content of acidic amino acids and leucine. These findings suggest that BJcuL, like other snake venom lectins, possesses structural similarities to the carbohydrate recognition domain (CRD) of calcium-dependent animal lectins belonging to the C-type -galactoside binding lectin family. |
| |
Keywords: | Snake venom Bothrops jararacussu C-type lectin amino acid sequence |
本文献已被 PubMed SpringerLink 等数据库收录! |