AC133+ progenitor cells as gene delivery vehicle and cellular probe in subcutaneous tumor models: a preliminary study |
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| Authors: | Ali M Rad ASM Iskander Branislava Janic Robert A Knight Ali S Arbab Hamid Soltanian-Zadeh |
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| Institution: | (1) Department of Radiology, Henry Ford Hospital, Detroit, Michigan, USA;(2) Department of Radiology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA;(3) Department of Neurology, Henry Ford Hospital, Detroit, Michigan, USA;(4) Control and Intelligent Processing Center of Excellence, Department of Electrical and Computer Engineering, University of Tehran, Tehran, Iran |
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| Abstract: | Background Despite enormous progress in gene therapy for breast cancer, an optimal systemic vehicle for delivering gene products to the
target tissue is still lacking. The purpose of this study was to determine whether AC133+ progenitor cells (APC) can be used
as both gene delivery vehicles and cellular probes for magnetic resonance imaging (MRI). In this study, we used superparamagentic
iron oxide (SPIO)-labeled APCs to carry the human sodium iodide symporter (hNIS) gene to the sites of implanted breast cancer
in mouse model. In vivo real time tracking of these cells was performed by MRI and expression of hNIS was determined by Tc-99m
pertechnetate (Tc-99m) scan. |
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