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Differential stepwise evolution of SARS coronavirus functional proteins in different host species |
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| Authors: | Xianchun Tang Gang Li Nikos Vasilakis Yuan Zhang Zhengli Shi Yang Zhong Lin-Fa Wang Shuyi Zhang |
| Affiliation: | (1) School of Life Science, East China Normal University, Shanghai, 200062, PR China;(2) Current address: Center for Vaccine Research, University of Pittsburgh, Pennsylvania, 15261, USA;(3) School of Life Sciences, Fudan University, Shanghai, 200433, PR China;(4) Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, PR China;(5) Australian Animal Health Laboratory and Australian Biosecurity Cooperative Research Centre, CSIRO Livestock Industries, Geelong, Victoria, 3220, Australia |
| Abstract: | BackgroundSARS coronavirus (SARS-CoV) was identified as the etiological agent of SARS, and extensive investigations indicated that it originated from an animal source (probably bats) and was recently introduced into the human population via wildlife animals from wet markets in southern China. Previous studies revealed that the spike (S) protein of SARS had experienced adaptive evolution, but whether other functional proteins of SARS have undergone adaptive evolution is not known. |
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