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Using in silico models to simulate dual perturbation experiments: procedure development and interpretation of outcomes
Authors:Neema Jamshidi  Bernhard O Palsson
Institution:(1) Department of Bioengineering, University of California, 9500 Gilman Drive, San Diego, La Jolla, CA 92093-0412, USA
Abstract:

Background  

A growing number of realistic in silico models of metabolic functions are being formulated and can serve as 'dry lab' platforms to prototype and simulate experiments before they are performed. For example, dual perturbation experiments that vary both genetic and environmental parameters can readily be simulated in silico. Genetic and environmental perturbations were applied to a cell-scale model of the human erythrocyte and subsequently investigated.
Keywords:
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