Association of virulence plasmid and antibiotic resistance determinants with chromosomal multilocus genotypes in Mexican Salmonella enterica serovar Typhimurium strains |
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| Authors: | Magdalena Wiesner Mussaret B Zaidi Edmundo Calva Marcos Fernández-Mora Juan J Calva and Claudia Silva |
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| Institution: | (1) Departamento de Microbiolog?a Molecular, Instituto de Biotecnolog?a, Universidad Nacional Aut?noma de M?xico, Cuernavaca, M?xico;(2) Laboratorio de Investigaci?n, Hospital General O'Horan, M?rida, M?xico;(3) Instituto Nacional de Ciencias M?dicas y de la Nutrici?n "Salvador Zubir?n", M?xico City, M?xico |
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| Abstract: | Background Bacterial genomes are mosaic structures composed of genes present in every strain of the same species (core genome), and genes
present in some but not all strains of a species (accessory genome). The aim of this study was to compare the genetic diversity
of core and accessory genes of a Salmonella enterica subspecies enterica serovar Typhimurium (Typhimurium) population isolated from food-animal and human sources in four regions of Mexico. Multilocus
sequence typing (MLST) and macrorestriction fingerprints by pulsed-field gel electrophoresis (PFGE) were used to address the
core genetic variation, and genes involved in pathogenesis and antibiotic resistance were selected to evaluate the accessory
genome. |
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