Identification and preliminary characterization of mouse Adam33 |
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| Authors: | Teresa M Gunn Arezou Azarani Philip H Kim Richard W Hyman Ronald W Davis Gregory S Barsh |
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| Affiliation: | (1) Departments of Pediatrics and Genetics, and the Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA, USA;(2) Department of Biochemistry and the Stanford DNA Sequencing and Technology Center, Stanford University School of Medicine, Stanford, CA, USA;(3) Department of Biomedical Sciences, Cornell University, Ithaca, NY, USA;(4) Robbins Scientific, Sunnyvale, CA, USA |
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| Abstract: | Background The metalloprotease-disintegrin family, or ADAM, proteins, are implicated in cell-cell interactions, cell fusion, and cell signaling, and are widely distributed among metazoan phyla. Orthologous relationships have been defined for a few ADAM proteins including ADAM10 (Kuzbanian), and ADAM17 (TACE), but evolutionary relationships are not clear for the majority of family members. Human ADAM33 refers to a testis cDNA clone that does not contain a complete open reading frame, but portions of the predicted protein are similar to Xenopus laevis ADAM13. |
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