Probing the importance and potential roles of the binding of the PH-domain protein Boi1 to acidic phospholipids |
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Authors: | Mark A Hallett H Shuen Lo Alan Bender |
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Institution: | (1) Department of Biology, Indiana University, Bloomington, IN 47405, USA;(2) Division of Nephrology, Indiana University Department of Medicine, 1120 South Dr., Indianapolis, IN 46202-5135, USA;(3) Laboratory of Population Genetics, National Institutes of Health, Room D702, 41 Library Drive, Bethesda, MD 20892, USA |
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Abstract: | Background The related proteins Boi1 and Boi2, which appear to promote polarized growth in S. cerevisiae, both contain a PH (pleckstrin homology) and an SH3 (src homology 3) domain. Previously, we gained evidence that a PH domain-bearing segment of Boi1, which we call Boi1-PH, is sufficient and necessary for function. In the current study, we investigate the binding of Boi1's PH domain to the acidic phospholipids PIP2 (phosphatidylinositol-4,5-bisphosphate) and PS (phosphatidylserine). |
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