Altered prostanoid production by fibroblasts cultured from the lungs of human subjects with idiopathic pulmonary fibrosis期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Altered prostanoid production by fibroblasts cultured from the lungs of human subjects with idiopathic pulmonary fibrosis

Authors:	Roberto Cruz-Gervis Arlene A Stecenko Ryszard Dworski Kirk B Lane James E Loyd Richard Pierson Gayle King Kenneth L Brigham

Affiliation:	(1) Center for Lung Research, Division of Allergy, Department of Medicine, Pulmonary and Critical Care Medicine, Vanderbilt University, Nashville, Tennessee, USA;(2) Department of Surgery, Vanderbilt University, Nashville, Tennessee, USA;(3) Department of Internal Medicine, Meharry Medical College, Nashville, Tennessee, USA

Abstract:	Background Prostanoids are known to participate in the process of fibrogenesis. Because lung fibroblasts produce prostanoids and are believed to play a central role in the pathogenesis of idiopathic pulmonary fibrosis (IPF), we hypothesized that fibroblasts (HF) cultured from the lungs of patients with IPF (HF-IPF) have an altered balance between profibrotic (thromboxane [TX]A₂) and antifibrotic (prostacyclin [PGI₂]) prostaglandins (PGs) when compared with normal human lung fibroblasts (HF-NL).

Keywords:	lung fibroblasts prostacyclin prostaglandins pulmonary fibrosis thromboxane
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