Unraveling lipid metabolism with microarrays: effects of arachidonate and docosahexaenoate acid on murine hepatic and hippocampal gene expression |
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| Authors: | Berger Alvin Mutch David M German J Bruce Roberts Matthew-Alan |
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| Affiliation: | (1) Department of Nutrition, University of North Carolina, 27599 Chapel Hill, NC, USA;(2) Head of Biochemistry, Metabolon, Inc, 800 Capitola Drive, Suite 1, 27713 Durham, NC, USA;(3) Director, Nestle Corporate Venture Funds, Acquisitions & Business Development, Nestle S.A., 55 Avenue Nestle, 1800 Vevey, Switzerland;(4) Director of Analytical Sciences, BioDiscovery, Inc., 100 North Sepulveda Blvd, Suite 1230, 90245 El Segundo, CA, USA |
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| Abstract: | Introduction The functions, actions, and regulation of polyunsaturated fatty acids (PUFAs) are just now beginning to be unraveled, in large due to modern molecular techniques. In the present work, mice were fed diets rich in either arachidonic acid (AA, n6), docosahexaenoic acid (DHA, n3), or the combination (AA+DHA). Both liver and hippocampus tissue were then analyzed through a combined gene expression-, lipid-, and behavioral- profiling strategy in order to annotate the molecular functions and targets of dietary PUFA. |
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