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Cellular immune response to Plasmodium falciparum after pregnancy is related to previous placental infection and parity |
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| Authors: | Nadine Fievet Germaine Tami Bertrand Maubert Marlène Moussa Ian K Shaw Michel Cot Anthony A Holder Gérard Chaouat Philippe Deloron |
| Affiliation: | 1. UR R010, Mother and Child Health in the Tropics, Institut de Recherche pour le Développement (IRD), Faculté de Pharmacie, 75006, Paris, France 2. Organisation de Coordination pour la Lutte contre les Endémies en Afrique Centrale (OCEAC), Yaoundé, Cameroon 3. INSERM U131, H?pital Antoine Béclère, Clamart, France 4. Division of Parasitology, National Institute for Medical Research, London, UK 5. Author's present address: Bertrand Maubert, Institut Pasteur de Cayenne, Guyane Fran?aise |
| Abstract: | BackgroundMalaria in pregnancy is characterised by the sequestration of Plasmodium falciparum -infected erythrocytes in placental intervillous spaces. Placental parasites express a specific phenotype, which allows them to cytoadhere to chondroitin sulfate A expressed by syncytiotrophoblasts. Malaria infection during pregnancy allows the acquisition of antibodies against placental parasites, these antibodies are thought to be involved in protection during subsequent pregnancies. |
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