美常安联合柳氮磺吡啶治疗溃疡性结肠炎的疗效及对血清TNF-alpha、IL-6、IL-8水平的影响

目的：探索美常安联合柳氮磺吡啶治疗溃疡性结肠炎（UC）的疗效，及对血清TNF-alpha、IL-6、IL-8 水平的影响。方法：选择自2012 年9月至2014 年12 月我院收治的100例UC 患者，按照随机数表法分成对照组和观察组，每组50 例。对照组患者口服给予柳氮磺吡啶，观察组患者口服给予美常安联合柳氮磺吡啶治疗。统计分析两组患者的临床有效率、症状改善、不良反应发生情况及治疗前后患者血清中TNF-alpha、IL-6、IL-8 水平的变化。结果：观察组中总有效率为92.00%显著高于对照组中总有效率为48.00%（P<0.05）；两组患者治疗后的主要临床症状较治疗前均有明显改善（P<0.05），且观察组患者治疗后主要症状缓解率明显高于对照组（P<0.05）；两组患者治疗后血清中TNF-alpha、IL-6、IL-8 水平均显著低于治疗前，且观察组明显低于对照组（P<0.05）；两组患者不良反应发生率之间的差异无统计学意义（P>0.05）。结论：美常安联合柳氮磺吡啶治疗UC具有良好的临床疗效，能显著改善患者的临床症状和患者血清中炎症因子的水平，值得在临床上推广使用。

Ulcerative Colitis: Efficacy of Meichangan plus Sulfasalazine and ItsInfluence on SerumTNF-alpha, IL-6, IL-8

Objective:To explore the efficacy of Meichangan combined with sulfasalazine in treatment of ulcerative colitis(UC)and its influence on the serum TNF-alpha, IL-6, IL-8.Methods:A total of 100 patients with UC, who were treated in Guilin Second People''sHospital from September 2012 to December 2014, were randomly divided into control group (n=50) and observation group (n=50). Thecontrol group was treated with sulfasalazine, while the observation group was treated with Meichangan combined with sulfasalazine. Theclinical efficacy, clinical symptoms improvement, incidence of adverse reactions, and the changes of serum TNF-alpha, IL-6, IL-8 levelbefore and after treatment in the two groups were statistically analyzed.Results:The total effective rate(92.00%) in the observation groupwas significantly higher than that(48.00%) in the control group(P<0.05); The main clinical symptoms of two groups after treatment weresignificantly improved than before treatment (P<0.05), meanwhile the main symptom remission rate after treatment in observation groupwas obviously higher than that in control group (P<0.05). The serum TNF-alpha, IL-6, IL-8 levels in the two groups after treatment weresignificantly lower than before treatment, the above indexes in observation group were significantly lower than those in control group(P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05).Conclusion:Meichangan plus sulfasalazine has a good clinical effect in the treatment of patients with UC, and it can significantly improve the clinicalsymptoms and reduce the serumTNF-alpha, IL-6, IL-8 levels, which is worth of clinical application.