成纤维细胞激活蛋白alpha与肿瘤免疫抑制的研究进展 |
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引用本文: | 曲雪梅 张健 丁婷婷 杨晓燕 陈鹤. 成纤维细胞激活蛋白alpha与肿瘤免疫抑制的研究进展[J]. 现代生物医学进展, 2016, 16(13): 2563-2566 |
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作者姓名: | 曲雪梅 张健 丁婷婷 杨晓燕 陈鹤 |
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作者单位: | 哈尔滨医科大学病理教研室 |
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基金项目: | 黑龙江省自然科学基金项目(D201049) |
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摘 要: | 成纤维细胞激活蛋白alpha(Fibroblast activation protein-alpha,FAP-alpha)是一种跨膜丝氨酸蛋白酶,高度表达在90 %的上皮性肿瘤的间质--肿瘤相关成纤维细胞(Tumor association fibroblast,TAF)上。FAPalpha在促进上皮性肿瘤的恶性进展中起着十分重要的作用,近年来研究发现,FAP琢在肿瘤微环境中发挥免疫抑制的作用。研究FAPalpha在肿瘤免疫抑制中的作用,已成为肿瘤研究的新的热点。为基于以FAP-alpha为靶标的抗肿瘤免疫治疗提供参考,本文围绕引起肿瘤免疫抑制的因素、FAPalpha与肿瘤免疫抑制的研究进展以及FAP-alpha在肿瘤的发展进程的作用作一综述。
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关 键 词: | 肿瘤微环境;成纤维细胞激活蛋白-alpha;肿瘤免疫抑制 |
Research Progress of Fibroblast Activation Protein alpha and TumorImmunosuppression |
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Abstract: | Fibroblast activation protein alpha(FAP-alpha) is a transmembrane serine protease and highly expressed in tumor associatedfibroblasts (TAF) in human epithelial tumors greater than 90 %. FAP-alpha plays a very important role in the malignant progression of epithelialtumors. In recent years, the study has found that FAP-alpha plays an important role in tumor microenvironment. Studying the role ofFAP-alpha in tumor suppression has become a new hot spot in tumor research. Based on FAP-alpha as the target of anti-tumor immune therapy toprovide the reference, the causes of tumor immune suppression, the research progress of FAP-alpha and tumor immunosuppression and therole of FAP -alpha in tumor progression are reviewed. |
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Keywords: | Tumor microenvironment Fibroblast activation protein-alpha(FAP-alpha) Tumor immune suppression |
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