成纤维细胞激活蛋白alpha与肿瘤免疫抑制的研究进展

成纤维细胞激活蛋白alpha（Fibroblast activation protein-alpha，FAP-alpha）是一种跨膜丝氨酸蛋白酶，高度表达在90 %的上皮性肿瘤的间质--肿瘤相关成纤维细胞（Tumor association fibroblast，TAF）上。FAPalpha在促进上皮性肿瘤的恶性进展中起着十分重要的作用，近年来研究发现，FAP琢在肿瘤微环境中发挥免疫抑制的作用。研究FAPalpha在肿瘤免疫抑制中的作用，已成为肿瘤研究的新的热点。为基于以FAP-alpha为靶标的抗肿瘤免疫治疗提供参考，本文围绕引起肿瘤免疫抑制的因素、FAPalpha与肿瘤免疫抑制的研究进展以及FAP-alpha在肿瘤的发展进程的作用作一综述。

Research Progress of Fibroblast Activation Protein alpha and TumorImmunosuppression

Fibroblast activation protein alpha(FAP-alpha) is a transmembrane serine protease and highly expressed in tumor associatedfibroblasts (TAF) in human epithelial tumors greater than 90 %. FAP-alpha plays a very important role in the malignant progression of epithelialtumors. In recent years, the study has found that FAP-alpha plays an important role in tumor microenvironment. Studying the role ofFAP-alpha in tumor suppression has become a new hot spot in tumor research. Based on FAP-alpha as the target of anti-tumor immune therapy toprovide the reference, the causes of tumor immune suppression, the research progress of FAP-alpha and tumor immunosuppression and therole of FAP -alpha in tumor progression are reviewed.