Inactivation of the Huntington's disease gene (Hdh) impairs anterior streak formation and early patterning of the mouse embryo |
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| Authors: | Juliana M Woda Teresa Calzonetti Paige Hilditch-Maguire Mabel P Duyao Ronald A Conlon and Marcy E MacDonald |
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| Institution: | (1) Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, CNY-149, 13th Street, 02129 Charlestown, MA, USA;(2) Department of Genetics, Case Western Reserve University, 1090 Euclid Avenue, 44106 Cleveland, OH, USA;(3) Faculty of Health Sciences, University of Queensland, 4072 St Lucia, QLD, Australia;(4) Department of Pathology, Harvard Medical School, 77 Avenue Louis Pasteur, NRB-850A, 02115 Boston, MA, USA |
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| Abstract: | Background Huntingtin, the HD gene encoded protein mutated by polyglutamine expansion in Huntington's disease, is required in extraembryonic tissues for
proper gastrulation, implicating its activities in nutrition or patterning of the developing embryo. To test these possibilities,
we have used whole mount in situ hybridization to examine embryonic patterning and morphogenesis in homozygous Hdh
ex4/5huntingtin deficient embryos. |
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