Cell-contact mediated modulation of the sialylation of contactinhibin |
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Authors: | Raimund J. Wieser Claudia E. Baumann Franz Oesch |
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Affiliation: | (1) Institute of Toxicology, Obere Zahlbacherstrae 67, 55131 Mainz, Germany |
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Abstract: | Contactinhibin was found to be involved in contact-dependent inhibition of growth. The growth inhibitory activity of contactinhibin is mediated by N-linked oligosaccharides with desialylated -glycosidically linked, terminal galactose residues. Here we show that in sparse human fibroblasts contactinhibin was expressed in a biologically inactive, highly sialylated form both on the plasma membrane and intracellularily, while in confluent cells plasma membrane localized contactinhibin was present in a biologically active, low sialylated form. Plasma membranes were shown to contain a glycoprotein sialidase which is suggested to be engaged in the activation of contactinhibin in a cell contact-dependent manner. |
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Keywords: | sialylation contact-inhibition |
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