iQuantitator: A tool for protein expression inference using iTRAQ |
| |
| Authors: | John H Schwacke Elizabeth G Hill Edward L Krug Susana Comte-Walters Kevin L Schey |
| |
| Affiliation: | (1) Department of Biochemistry, Medical University of South Carolina, Charleston, South Carolina, USA;(2) Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA;(3) Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, South Carolina, USA;(4) Department of Pharmacology, Medical University of South Carolina, Charleston, South Carolina, USA;(5) Mass Spectrometry Research Center, Vanderbilt University, Nashville, Tennessee, USA |
| |
| Abstract: | Background Isobaric Tags for Relative and Absolute Quantitation (iTRAQ™) [Applied Biosystems] have seen increased application in differential protein expression analysis. To facilitate the growing need to analyze iTRAQ data, especially for cases involving multiple iTRAQ experiments, we have developed a modeling approach, statistical methods, and tools for estimating the relative changes in protein expression under various treatments and experimental conditions. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
