Identification, distribution and molecular evolution of the pacifastin gene family in Metazoa |
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| Authors: | Bert Breugelmans Gert Simonet Vincent van Hoef Sofie Van Soest Vanden Jozef Broeck |
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| Affiliation: | (1) Department of Animal Physiology and Neurobiology, Zoological Institute K.U.Leuven, Naamsestraat 59, B-3000 Leuven, Belgium |
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| Abstract: | Background Members of the pacifastin family are serine peptidase inhibitors, most of which are produced as multi domain precursor proteins. Structural and biochemical characteristics of insect pacifastin-like peptides have been studied intensively, but only one inhibitor has been functionally characterised. Recent sequencing projects of metazoan genomes have created an unprecedented opportunity to explore the distribution, evolution and functional diversification of pacifastin genes in the animal kingdom. |
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