Migration of CD18-deficient neutrophils in vitro: evidence for a CD18-independent pathway induced by IL-8 |
| |
Authors: | Morland C M Morland B J Darbyshire P J Stockley R A |
| |
Institution: | Department of Medicine, Queen Elizabeth Hospital, Edgbaston, Birmingham, UK. |
| |
Abstract: | Neutrophils isolated from a child with severe leukocyte adhesion deficiency 1 (LAD1) had a complete absence of expression of the CD11/CD18 beta2 integrin family of adhesion molecules, and were shown to be deficient in the in vitro adhesion and migration properties. However, we found that interleukin-8 (IL8), a potent chemoattractant for neutrophils, and sputum sol phase induced these LAD1 neutrophils to migrate through an endothelial cell layer in vitro, and confirmed that this migration was CD18-independent. These findings add to evidence of CD18-independent mechanisms of neutrophil recruitment, in particular neutrophil infiltration into the lungs, where IL8 may be an important recruitment factor. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|