Anisakis simplex s.l.: Larvicidal activity of various monoterpenic derivatives of natural origin against L3 larvae in vitro and in vivo |
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| Authors: | Navarro M C Noguera M A Romero M C Montilla M P González de Selgas J M Valero A |
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| Institution: | aDepartamento de Farmacología, Facultad de Farmacia, Universidad de Granada, Campus de Cartuja, 18071 Granada, Spain;bDepartamento de Parasitología, Facultad de Farmacia, Universidad de Granada, Campus de Cartuja, 18071 Granada, Spain;cServicio de Farmacia, Hospital de San Cecilio, Universidad de Granada, 18071 Granada, Spain |
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| Abstract: | This paper describes the activity against Anisakis simplex s.l. L3 larvae of six monoterpenic derivatives obtained from different essential oils, (α-pinene, β-pinene, ocimene, myrcene, geranyl acetate, and cineole). In in vitro assays, α-pinene, ocimene and cineole showed high activity at a concentration of 125 μg/mL (48 h) but only α-pinene and ocimene were active at 62.5 μg/mL. In in vivo assays, L3 larvae and study compounds were simultaneously administered per os to Wistar rats. The most active compound was α-pinene, finding lesions in only 20% of treated rats versus 98% of controls. Further in vivo studies are required to investigate whether addition of these compounds to food could have a prophylactic effect, reducing the pathogenicity of A. simplex s.l. L3 in humans, and to explore any possible synergy among compounds. |
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| Keywords: | Anisakis simplex s l Larvicidal activity Monoterpenic derivatives α-Pinene Ocimene |
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