Superoxide dismutase of bovine and frog rod outer segments. |
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| Authors: | M O Hall D O Hall |
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| Institution: | Jules Stein Eye Institute, The Center for the Health Sciences, University of California, Los Angeles, CA 90024, USA;University of London King''s College, Department of Plant Sciences, 68 Half Moon Lane, London SE24 9JF, UK |
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| Abstract: | Bovine rod outer segments (ROS) contain soluble superoxide dismutase (SOD) which from cyanide sensitivity and electrophoretic mobility appears identical to CuZn SOD of erythrocytes. Enzyme activity of ROS extracts is 200–400 times as much as remainder of retina. Frog ROS also contains a cyanide-sensitive SOD which is not due to erythrocyte contamination since the retina is avascular. SOD in ROS may inhibit free radical oxidation of polyunsaturated fatty acids. In light, high oxygen concentrations in developing retina may activate lipid peroxidation leading to retrolental fibroplasia. High concentrations of ascorbic acid in the retina may act as a protective mechanism against superoxide. |
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