New water-soluble Mn-porphyrin with catalytic activity for superoxide dismutation and peroxynitrite decomposition |
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| Authors: | Asayama Shoichiro Nakajima Takumi Kawakami Hiroyoshi |
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| Affiliation: | Department of Applied Chemistry, Tokyo Metropolitan University, 1-1 Minami-Osawa, Hachioji, Tokyo, Japan. |
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| Abstract: | We have synthesized a new water-soluble cationic Mn-porphyrin with catalytic activity for both superoxide dismutation and peroxynitrite decomposition. The resulting Mn-porphyrin also showed higher stability for reactive oxygen species such as hydrogen peroxide and lower cytotoxicity, when compared with a control normal Mn-porphyrin. Furthermore, the new porphyrin recovered the viability of lipopolysaccharide-stimulated macrophage RAW 264.7 cells but the control Mn-porphyrin did not. |
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