Extending the Cellulosome Paradigm: the Modular Clostridium thermocellum Cellulosomal Serpin PinA Is a Broad-Spectrum Inhibitor of Subtilisin-Like Proteases |
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| Authors: | Páraic ó Cuív Rajesh Gupta Hareshwar P Goswami Mark Morrison |
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| Institution: | CSIRO Animal, Food and Health Sciences, Queensland Biosciences Precinct, St. Lucia, Queensland, Australiaa;The Ohio State University, Columbus, Ohio, USAb |
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| Abstract: | Clostridium thermocellum encodes a cellulosomal, modular, and thermostable serine protease inhibitor (serpin), PinA. PinA stability but not inhibitory activity is affected by the Fn(III) and Doc(I) domains, and PinA is a broad inhibitor of subtilisin-like proteases and may play a key role in protecting the cellulosome from protease attack. |
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