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Evidence for a Tumor Suppressor Role for the Large Tumor Suppressor Genes LATS1 and LATS2 in Human Cancer |
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| Authors: | Tian Yu John Bachman Zhi-Chun Lai |
| Affiliation: | *Intercollege Graduate Degree Program in Cell and Developmental Biology, The Pennsylvania State University, University Park, Pennsylvania 16802;†Department of Biology, The Pennsylvania State University, University Park, Pennsylvania 16802;‡Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802 |
| Abstract: | The role of Large tumor suppressor LATS/Warts in human cancer is not clearly understood. Here we show that hLATS1/2 cancer mutations affect their expression and kinase activity. hLATS1/2 mutants exhibit a decreased activity in inhibiting YAP and tissue growth. Therefore, hLATS1/2 alleles from human cancer can be loss-of-function mutations. |
| Keywords: | Hippo signaling human cancer LATS1 LATS2 protein kinase |