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Leveraging gene co-regulation to identify gene sets enriched for disease heritability
Affiliation:1. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA;2. Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA;3. Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02142, USA;4. Program in Systems, Synthetic, and Quantitative Biology, Harvard University, Cambridge, MA 02138, USA;5. Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA
Abstract:
Keywords:gene set analysis  gene expression  heritability enrichment  pathway analysis  TWAS  genetic architecture  co-regulation
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