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A transchromosomic rat model with human chromosome 21 shows robust Down syndrome features
Authors:Yasuhiro Kazuki  Feng J Gao  Miho Yamakawa  Masumi Hirabayashi  Kanako Kazuki  Naoyo Kajitani  Sachiko Miyagawa-Tomita  Satoshi Abe  Makoto Sanbo  Hiromasa Hara  Hiroshi Kuniishi  Satoshi Ichisaka  Yoshio Hata  Moeka Koshima  Haruka Takayama  Shoko Takehara  Yuji Nakayama  Masaharu Hiratsuka  Yuichi Iida  Satoko Matsukura  Naohiro Noda  Yicong Li  Anna J Moyer  Bei Cheng  Nandini Singh  Joan T Richtsmeier  Mitsuo Oshimura  Roger H Reeves
Institution:1. Division of Genome and Cellular Functions, Department of Molecular and Cellular Biology, School of Life Science, Faculty of Medicine, Tottori University, 86 Nishi-cho, Yonago, Tottori 683-8503, Japan;2. Chromosome Engineering Research Center, Tottori University, Yonago, Tottori 683-8503, Japan;3. Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA;4. Center for Genetic Analysis of Behavior, National Institute for Physiological Sciences, Okazaki, Aichi 444-8787, Japan;5. Department of Animal Nursing Science, Yamazaki University of Animal Health Technology, Hachioji, Tokyo 192-0364, Japan;6. Department of Physiological Chemistry and Metabolism, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan;7. Trans Chromosomics, Inc., 86 Nishi-cho, Yonago, Tottori 683-8503, Japan;8. Division of Neuroscience, School of Life Science, Faculty of Medicine, Tottori University, 86 Nishi-cho, Yonago, Tottori 683-8503, Japan;9. Division of Radioisotope Science, Research Initiative Center, Organization for Research Initiative and Promotion, Tottori University, 86 Nishi-cho, Yonago, Tottori 683-8503, Japan;10. Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki 305-8566, Japan;11. Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA;12. Department of Anthropology, California State University, Sacramento, CA 95819, USA;13. Department of Anthropology, Penn State University, State College, PA 16802, USA;14. Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Abstract:
Keywords:Down syndrome  HSA21  transchromosomic  rat model  intellectual disability  hypoplasia  TcHSA21rat  TcMAC21
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