Probing 3-Hydroxyflavone for In Vitro Glycorandomization of Flavonols by YjiC |
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| Authors: | Ramesh Prasad Pandey Prakash Parajuli Niranjan Koirala Je Won Park Jae Kyung Sohng |
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| Affiliation: | Institute of Biomolecule Reconstruction (iBR), Department of Pharmaceutical Engineering, Sun Moon University, Tangjeong-myeon, Asan-si, Chungnam, Republic of Korea |
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| Abstract: | The glycosylation of five different flavonols, fisetin, quercetin, myricetin, kaempferol, and 3-hydroxyflavone, was achieved by applying YjiC. 3-Hydroxyflavone was selected as a probe for in vitro glycorandomization of all flavonols using diverse nucleotide diphosphate-d/l-sugars. This study unlocked the possibilities of the glycodiversification of flavonols and the generation of novel compounds as future therapeutics. |
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