Molecular polarity dependence of the transformed steroid effect on Na,K-ATPase |
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| Authors: | A V Kamernitski? I G Reshetova N M Mirsalikhova V G Levi E I Chernoburova |
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| Abstract: | The transformed steroids containing an additional cycle E (delta-lactone or 16.23-pyranone) or 23-carbethoxy side chain (1.10(-5) M) inhibit Na,K-ATPase from pig kidney medulla. The steroid structure has a noticeable effect on ATPase inhibiton varying from 9 to 35%. The data obtained suggest that the position, stereochemistry and the uneven distribution of polar substituents in the steroid molecule are essential for ATPase inhibition by steroid aglycons. |
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