Synthetic GPI array to study antitoxic malaria response |
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Authors: | Kamena Faustin Tamborrini Marco Liu Xinyu Kwon Yong-Uk Thompson Fiona Pluschke Gerd Seeberger Peter H |
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Institution: | Laboratory for Organic Chemistry, Swiss Federal Institute of Technology (ETH) Zurich, Wolfgang-Pauli-Str. 10, 8093 Zurich, Switzerland. |
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Abstract: | Parasite glycosylphosphatidylinositol (GPI) is an important toxin in malaria disease, and people living in malaria-endemic regions often produce high levels of anti-GPI antibodies. The natural anti-GPI antibody response needs to be understood to aid the design of an efficient carbohydrate-based antitoxin vaccine. We present a versatile approach based on a synthetic GPI glycan array to correlate anti-GPI antibody levels and protection from severe malaria. |
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