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Significance of enzyme degradation rate and enzyme inhibition in targeted chemotherapy |
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| Authors: | George Weber |
| Affiliation: | Laboratory for Experimental Oncology, Indiana University School of Medicine, 699 West Drive, RR 337, Indianapolis, IN 46202-5119, USA |
| Abstract: | |
| Keywords: | CdR kinase, deoxycytidine kinase (EC 2.7.1.74) DHFR, dihydrofolate reductase (EC 1.5.1.5) 5-FU, 5-fluorouracil GPRT, guanine phosphoribosyltransferase (EC 2.4.2.8) IMP DH, inosine 5&prime -monophosphate dehydrogenase (EC 1.1.1.205) MTX, methotrexate TAD, thiazole-4-carboxamide adenine dinucleotide TK, TdR (thymidine) kinase (EC 2.7.1.21) dTMP, deoxythymidylate dTMP synthase, TS, thymidylate synthase (EC 2.1.1.45) TR, tiazofurin, 2-β-D-ribofuranosylthiazole-4-carboxamide (NSC 286193) dUMP, deoxyuridylate |
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