Protection against electrophile and oxidative stress by induction of phase 2 genes: the quest for the elusive sensor that responds to inducers |
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| Authors: | W.David Holtzclaw |
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| Affiliation: | The Lewis B. and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA |
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| Abstract: | |
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| Keywords: | AHH, aryl hydrocarbon hydroxylase Ah receptor, aryl hydrocarbon receptor ARE (EpRE), antioxidant (electrophile) response element BHA, 2(3)-tert-butyl-4-hydroxyanisole t-BHQ, tert-butylhydroquinone BHT, 3,5-di-tert-butyl-4-hydroxytoluene BP, benzo(a)pyrene Dex-mes, dexamethasone 21-mesylate DMBA, dimethylbenz(a)anthracene GST, glutathione S-transferase (EC 2.5.1.18) Keap1, kelch-like ECH-associated protein 1 MARE, Maf recognition element β-NF, β-naphthoflavone NQO1, NAD(P)H:quinone oxidoreductase (also known as quinone reductase, DT diaphorase, menadione reductase, EC 1.6.99.2) Nrf2, NF-E2-related factor 2 PAH, polycyclic aromatic hydrocarbons TCDD, dioxin, 2,3,7,8-tetrachlorodibenzo-p-dioxin TPA, 12-O-tetradecanoylphorbol 13-acetate TRE, TPA response element XRE, xenobiotic response element |
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