Synthesis and evaluation of anti-HSV activity of new 5-alkynyl-2'-deoxyuridines |
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| Authors: | Pchelintseva A A Skorobogatyj M V Petrunina A L Andronova V L Galegov G A Astakhova I V Ustinov A V Malakhov A D Korshun Vladimir A |
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| Institution: | Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia. |
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| Abstract: | Eight 5-alkynyl-2'deoxyuridines containing different bulky substituents have been prepared and tested against HSV-1 in Vero cells. The compounds show positive antiviral activity. There is no obvious correlation between activity and substituent size. The nature of the linker between uracil and a substituent appears to be more important for antiviral properties: nucleosides containing arylethynyl groups show higher activity. |
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